Hypermobility means having joints that move beyond the normal range of motion — often described as being very flexible or “double‑jointed.” While some people are simply flexible without issues, others experience pain, instability, or frequent injuries.
One of the most well‑known causes of symptomatic hypermobility is Ehlers‑Danlos Syndrome (EDS). EDS is a group of genetic connective tissue disorders that affect collagen — the protein that provides structure and support to the skin, joints, blood vessels, and other tissues.
Because collagen plays such a large role throughout the body, EDS can affect far more than just joints. Understanding these connections can help patients feel validated and receive more effective, whole‑body care.
What Is Ehlers‑Danlos Syndrome (EDS)?
EDS causes connective tissue to be more elastic and less stable than usual. As a result, people with EDS often experience:
- Overly flexible or unstable joints
- Frequent joint pain
- Partial or full joint dislocations
- Fragile skin or slow wound healing (in some types)
Learn more from the Mayo Clinic: – EDS – Symptoms & Causes (Mayo Clinic) – EDS – Diagnosis & Treatment (Mayo Clinic)
Why Physical Therapy Is Essential for Hypermobility
Physical therapy is a cornerstone of managing hypermobility and hypermobile EDS.
Rather than stretching already‑loose joints, PT focuses on:
- Improving joint stability
- Strengthening muscles that support lax joints
- Training the nervous system to keep joints in safe, neutral positions
- Reducing pain and injury risk
Research consistently shows that exercise‑based therapy is a primary treatment for hypermobile EDS, helping protect joints and improve quality of life.
At PT2Excel in Thurston County, WA, our physical therapy team is experienced in treating hypermobility. We design targeted, individualized programs to help patients feel stronger, safer, and more confident in their movement.
More on current treatment guidance: – New Treatment Guidance for Hypermobility & GI Symptoms (MDedge)
Common Health Issues That Often Occur With Hypermobility
Because connective tissue exists throughout the body, hypermobility and EDS often come with seemingly unrelated symptoms. Below are some of the most common co‑occurring conditions.
Gastrointestinal (GI) Problems
Digestive issues are extremely common in people with hypermobile EDS.
Research from the American Gastroenterological Association suggests that up to 98% of people with hypermobile EDS experience some form of gastrointestinal disorder — most often functional GI disorders such as irritable bowel syndrome (IBS).
Common symptoms include: – Abdominal pain – Constipation or diarrhea – Bloating – Acid reflux
This may be related to connective tissue laxity in the gut and differences in nervous system signaling.
There is also growing evidence linking EDS with: – Postural Orthostatic Tachycardia Syndrome (POTS) – Mast Cell Activation Syndrome (MCAS)
Both can contribute to nausea, bloating, and digestive discomfort.
Helpful reads: – AGA Clinical Update on GI Manifestations in hEDS – EDS Overlaps: Moving Beyond the “Zebra” Diagnosis (Medscape)
In physical therapy, we modify exercises to reduce dizziness, reflux, or GI discomfort — such as avoiding positions that trigger symptoms and prioritizing gentle, well‑tolerated movement.
Allergies & Mast Cell Activation Syndrome (MCAS)
Many hypermobile patients experience allergy‑like symptoms due to Mast Cell Activation Syndrome (MCAS).
MCAS occurs when mast cells release excessive inflammatory chemicals, leading to symptoms such as:
- Flushing or redness
- Hives or itching
- Sneezing or wheezing
- Headaches
- GI flare‑ups
A 2024 Mayo Clinic study found that approximately 77% of hypermobile EDS patients reported allergy or atopy symptoms.
Learn more: – MCAS – Center for Complex Neurology – hEDS & Symptom Prevalence Study (PubMed Central)
At PT2Excel, we stay mindful of sensitivities by: – Using unscented or hypoallergenic products – Avoiding heat modalities when needed – Coordinating care with your medical providers
Neurodivergence (ADHD & Autism)
Emerging research shows a significant overlap between EDS and neurodevelopmental conditions, including ADHD and autism spectrum disorder (ASD).
A Swedish population study found that people with hypermobile EDS were more likely to have ADHD or ASD than the general population.
Common shared traits may include: – Sensory sensitivities – Differences in proprioception (body awareness) – Anxiety – Difficulty with attention or task sequencing
Helpful resource: – The Link Between Neurodiversity, Hypermobility & EDS – The EDS Clinic
In our clinic, we adapt therapy by offering: – Clear, step‑by‑step instructions – Visual cues or timers – A calm, structured, sensory‑friendly environment
Headaches & Migraines
Headaches and migraines are very common in people with hypermobility.
Possible contributors include: – Cervical spine (neck) instability – Overworked neck and shoulder muscles – Blood flow changes related to POTS
Studies show that more than half of hypermobile patients experience regular headaches or migraines.
Learn more: – Headaches in Ehlers‑Danlos Syndromes – Jeannie Di Bon
Physical therapy can help by: – Improving posture – Strengthening neck and shoulder stabilizers – Teaching gentle cervical stabilization exercises – Addressing ergonomics and sleep positioning
Dental & Jaw (TMJ) Issues
EDS can also affect oral and dental health.
Common concerns include: – Fragile oral tissues or frequent mouth sores – Gum recession or bleeding – Jaw subluxations or dislocations – TMJ pain or clicking – Softer tooth enamel in some EDS types
Helpful resources: – Oral & Dental Implications of EDS – The Ehlers‑Danlos Society – Jaw Dislocation & EDS – BMJ – EDS – UM Health Sparrow
In physical therapy, we assess jaw posture, neck alignment, and muscle tension. When needed, we collaborate with dentists or TMJ specialists to support comprehensive care.
Empowering Patients Through Awareness
Living with hypermobility or EDS can feel overwhelming — especially when symptoms affect multiple body systems.
The most important takeaway is this:
Your symptoms are connected — and they are valid.
Joint pain, digestive issues, allergies, headaches, sensory sensitivities, and jaw problems often stem from the same connective tissue differences.
At PT2Excel, we take a holistic, whole‑body approach. We listen, adapt, and coordinate care so you can move safely, reduce pain, and feel more in control of your body.
If you have questions about how hypermobility or EDS may be affecting you, we’re here to help — joint by joint, and beyond.
